Vol 34(2018) N 3 p. 67-77; DOI 10.21519/0234-2758-2018-34-3-67-77
E.A. Nikitina1,2*, D.A. Chernikova2, O.V. Vasilyeva3**, A.V. Zhuravlev1, A.V. Medvedeva1, N.S. Domnina4, O.Yu. Sergeeva4, V.B. Vol'eva5, B.F. Shchegolev1, E.V Savvateeva-Popova1

Effect of Antioxidants on Medium-Term Memory Formation in Drosophila melanogaster cardinal Mutant

1The Pavlov Institute of Physiology, Russ. Acad. Sci., 199034, St-Petersburg
2The Herzen Russian State Pedagogical University, 191186, St-Petersburg
3The Gorynin Central Research Institute of Structural Materials "Prometey", National Research Centre "Kurchatov Institute" (NRC "Kurchatov Institute"-CRISM "Prometey"), 191015, St-Petersburg
4The Saint-Petersburg State University, 199034, St-Petersburg
5The Emanuel Institute of Biochemical Physics, Russ. Acad. Sci., 119334, Moscow

Received - 03.04.2018; Accepted - 04.05.2018


Disturbances of the kynurenine pathway of the tryptophan metabolism are one of the causes for the neurodegeneration development in brain. Some metabolites of this pathway (3-hydroxykynurenine) induce the processes of free radical oxidation in neuronal cell cultures that causes cell death. It has been shown that polymeric antioxidants improve middle-term memory formation in a D. melanogaster cardinal mutant under stressful conditions due to the accumulation of 3-hydroxykynurenine. In order to theoretically predict the activity of phenolic antioxidant β-(4-hydroxy-3,5-di-tert-bulylphenyl)propionic acid, 3-hydroxykynurenine and polyethylenglycol, quantum chemical calculations of the dissociation energy of their OH-groups, H atom donors, were performed. It was shown that β-(4-hydroxy-3,5-di-tert-bulylphenyl)propionic acid and 3-hydroxykynurenine can easily release the hydroxyl H atom which may provide their antioxidant properties.

Drosophila, quantum chemical calculations, learning, memory, polyethylene glycol, phenolic antioxidants, 3-hydroxykynurenine.

This study was supported by the Program of Fundamental Scientific Research of State Academies for 2013-2020 (GP-14, section 63).